Leaders of the Ghana Premier League (GPL) Medeama SC will be away to Berekum Chelsea in the top liner of Wednesday's games in the competition.
The Mauve and Yellow, are five points clear at the top of the stairs as they seek a second GPL title.
They go into this game against a relegation-threatened Berekum Chelsea side who will look to make the most of the home conditions to stay above the relegation zone.
Chelsea, are two points clear from the bottom three, and a win this afternoon can move them to the 10th position if results elsewhere favours them.
What ever happens in this afternoon's encounter, Medeama SC will stay top of the standing but, they will look for the win to bolster their chances of clinching their second Ghanaian top-flight title.
In other games this afternoon, second placed Gold Stars will host FC Samartex at the Dun's Park, Bibiani.
Title chasing Accra Hearts of Oak who are third on the log, will be home to Karela United at the Accra Sports Stadium.
Swedru All Blacks will look to move further clear of trouble as they host already relegated Eleven Wonders at the Swedru Sports Stadium.
Young Apostles are in the bottom three and they host Vision FC at the Wenchi Sports Stadium.
Dreams FC are in the Ahafo region to play Bechem United at the Nana Fosu Gyeabour Park, Bechem.
Basake Holy Stars hosts Aduana FC at the AAK II Sports Arena, Azulewanu as they seek to maintain their status for another season.
Nations FC will be away to Heart of Lions at the Kpando Sports Stadium, looking for a breather to calm their nerves.
